Digital Health Investors: who’s writing the checks.

The original dedicated digital health venture fund (founded 2010). Invests pre-seed through Series A in software- and data-driven health companies. Sister firm Rock Health Advisory advises Fortune 500 clients on digital health strategy. Notable portfolio: Omada Health, Collective Health, 100+ companies.

Best fit: Care delivery, consumer health

Chicago-based seed-to-Series A digital health investor empowering informed, connected health consumers. Notable for backing Transcarent (unicorn), Livongo (acquired by Teladoc), Higi, HomeThrive. ~42 portfolio companies. Founders Glen Tullman, Lee Shapiro bring operator depth.

Best fit: Consumer health, care navigation

Boston-based healthcare technology specialist with $350M latest fund. Series A-C focus, $5M-$30M checks. One of the most active U.S. digital health investors in 2024 (16 deals). Notable: Bright Health, HealthVerity, Aetion, HealthifyMe, Oshi Health.

Best fit: Healthcare SaaS, payer-tech

Seed-stage digital health specialist focused on care delivery innovation and digital health infrastructure. Notable: Marley Medical, Turquoise Health. Operates with deep clinical and operator network. $500K-$2M initial checks.

Best fit: Care delivery infrastructure

Seed-stage firm investing in healthcare software and AI-driven services solving operational and clinical bottlenecks. Team includes investors, operators, and former policymakers. Portfolio: Brellium, Claim Health, UrgentIQ, ArcHouse, Cybexys.

Best fit: Healthcare AI, workflow & ops

NYC-based fund (founded 2019) focused on vertical specialty care, digital therapeutics, and healthcare IT. Founder Adam Besvinick brings nearly a decade of digital health investing. Avoids hardware, biotech, and life sciences. Notable: Hone Health, Sylvan Health.

Best fit: Vertical specialty care, DTx

Pre-seed and seed fund bringing frontline clinical insight to digital health, health IT, tech-enabled services, and Class I/II medical devices. $100K-$300K checks. Built by clinicians for clinician-founders. Notable: Posterity Health, Conceivable Life Sciences.

Best fit: Clinician-led, FDA-regulated

Austin-based pre-seed and seed venture firm exclusively partnering with healthcare founders in the first 12-24 months. Focuses on the “business of care” (data, dollars, delivery). Avoids biotech, devices, and therapeutics. Founded 2021.

Best fit: Care delivery, healthcare ops

Barcelona-based seed-stage VC exclusively dedicated to healthtech. Invests in early-stage companies across Europe and globally. €100K-€1M typical investments. Bridges European healthcare innovators with international markets.

Best fit: European healthtech

Germany’s leading early-stage tech investor. Backs deep-tech, digital health, and AI startups from pre-seed to seed. Initial €800K+ with follow-on up to €30M. Public-private fund-of-funds with co-investment network.

Best fit: Deep-tech, clinical infrastructure

London-based early-stage venture firm backing global-market startups in healthtech, AI/ML, fintech, and software. One of Europe’s most prolific seed funds with thousands of portfolio companies. Founded 2007.

Best fit: European pre-seed (multi-vertical)

Zurich-based digital health and health IT seed/Series A specialist. Pan-European focus on regulated healthtech, AI, and clinical-grade infrastructure. Operator-led with deep DACH-region network.

Best fit: European clinical-grade infrastructure

Early-stage venture fund (founded 2021) seeding the next generation of digital health, healthtech, and longevity startups focused on extending human healthspan. Seed and Series A focus on the democratization of medicine. Portfolio: Sanctuary AI, Biotia, Immunis, BeeKeeper AI, CardiaTec. Co-founded by Ricky Mehra and Daniel Kraft, MD.

Best fit: Longevity & healthspan

Seattle-based healthcare technology investor focused on digital health, devices, oral health, healthcare SaaS, consumerization, and wellness. Seed-stage specialist with active platform-supporting model. Focus on category-defining commercial-stage health-tech.

Best fit: Devices, oral health, consumer health

European pan-European pre-seed and seed firm with active healthtech vertical. Multi-stage capability with a sector-specialist team for digital health and life sciences. €100K-€1M initial checks. One of the most active early-stage VCs in Europe.

Best fit: European pre-seed (multi-vertical)

a16z’s dedicated $1.5B+ healthcare fund. Most active digital health investor in 2024 (26 deals). Spans seed to growth, $1M-$100M+. Backs founders applying modern computer science to drug discovery and healthcare delivery. Partners include Vijay Pande, Julie Yoo, Jorge Conde.

Best fit: Healthcare AI, TechBio

Multi-stage VC with the Health Assurance Network leading the shift from sick care to proactive health. 30+ health-tech investments since 2021’s Health Assurance Fund launch. Notable: Devoted Health, Olive AI, Lyra Health, Transcarent.

Best fit: Health Assurance, care delivery

Alphabet’s venture arm with a strong digital health practice. Seed through growth, with deep computational and ML expertise. Top Femtech investor per Galen Growth HT50 2025. Notable: Flatiron Health, One Medical, Doctor on Demand.

Best fit: Healthcare AI, women's health

AI-first healthcare investor with strong technical conviction. Among the most active early-stage digital health investors, with 11 deals in 2024. Notable: Rad AI, C the Signs. Tolerates technical risk; non-consensus bets.

Best fit: Healthcare AI, clinical AI

50+ year history in healthcare and tech investing with deep healthcare IT, biotech, and tech-enabled services roots. Early and growth stages with focus on value-based care, digital health, and enterprise SaaS. Notable: Athenahealth, Devoted Health, Lyra Health, 10x Genomics.

Best fit: Value-based care, care delivery

Founded 1977. One of the largest global VC firms with dual tech/healthcare focus. Deploys across all stages with extensive regulatory networks for therapeutics and digital health platforms. Multi-billion fund cycles.

Best fit: Therapeutics + digital, multi-thesis

Storied Sand Hill Road firm investing in technology and health sectors at seed and Series A. Long history backing breakthrough health-tech companies. Notable health portfolio includes Headspace Health (formerly Ginger.io), Lyell Immunopharma.

Best fit: Healthcare SaaS, mental health

Early-stage VC investing in healthcare and technology visionaries. Strong digital health portfolio focused on access to care and patient outcomes. Co-led major rounds in care delivery, behavioral health, and clinical AI.

Best fit: Care delivery, behavioral health

Backs bold, frontier-tech companies pushing boundaries in healthcare, biotech, and deep science. Seed to growth stages with focus on AI, robotics, and next-gen therapeutics. Tolerates extreme technical risk.

Best fit: TechBio, frontier health

NYC-based early-stage firm with deep operational support. Health-tech portfolio includes companies in care delivery, digital therapeutics, and patient infrastructure. Active operating team works alongside founders.

Best fit: Care delivery, digital therapeutics

Deep-tech investor backing scientific and engineering breakthroughs. Healthcare portfolio focuses on computational biology, drug discovery, and clinical-grade AI. Seed to early venture rounds.

Best fit: Computational health, drug discovery

Pan-European multi-stage VC at the intersection of software and science. Backed digital health since 2006. Team of scientists, doctors, and operators. €500K-€5M initial checks with follow-on for scale.

Best fit: European software + science

San Francisco-based healthcare-focused investment firm spun out from Maverick Capital. Series A and growth-stage focus on healthcare AI, tech-enabled services, and scalable digital health platforms. Patient capital with a 10+ year horizon. Strong network of healthcare operators.

Best fit: Healthcare AI, tech-enabled services

Israeli-American venture creation foundry building category-defining healthcare AI, data infrastructure, and cybersecurity-adjacent healthcare companies from inception. Co-founds and capitalizes companies in partnership with global health systems and corporate strategics. Active in U.S. and Israel.

Best fit: Healthcare AI, data infrastructure, Israel/US

UK/European early-stage VC backing healthtech, digital care, clinical decision support, AI drug discovery, and healthcare infrastructure. Series A focus with follow-on capacity. Strong network across NHS and European health systems for clinical validation.

Best fit: European healthcare AI, digital care

Pan-European deep-tech investor (founded 2010, formerly Investiere) with a dedicated Health & Bio vertical alongside Digital and Tangible Tech. 150+ portfolio companies across Europe. Ranked the #3 European digital health investor per Galen Growth HT50 2025.

Best fit: European health & bio deep-tech

Healthcare and fintech specialist with deep care-delivery, payer-platform, and revenue-cycle expertise. Series B-growth, $5M-$100M+ checks. Notable: Athenahealth, VillageMD, Devoted Health, Cityblock Health.

Best fit: Value-based care, payer-tech

Multi-stage investor with broad health-tech portfolio. Series A-growth focus on healthcare SaaS leaders, cloud-based platforms, and consumer health. Founded 1911. Notable: Hims, Sword Health, PillPack.

Best fit: Healthcare SaaS, consumer health

#1 ranked early-stage digital health investor per Galen Growth HT50 2025 (Investor Score 90.8%). Premier global software investor applying B2B SaaS scaling methodology to healthcare. Onsite scaling team supports portfolio post-investment.

Best fit: Healthcare SaaS, scaling

Global VC arm of Fidelity Investments. Seed through growth in technology and healthcare. Focus on innovation and disruptive growth across digital health, biotech, medtech, and IT.

Best fit: Healthcare AI, infrastructure

Healthcare venture platform with health system connections. Series A-B, $5M-$20M. Notable: Phreesia (IPO), IntelyCare, Olive. Strategic LP base of major U.S. health systems gives portfolio commercial validation.

Best fit: Health system deployment

Operator-led healthcare fund with deep payer/provider network. Series A-B, $5M-$25M. Focus on care delivery, behavioral health, and labor enablement for digital health platforms with enterprise traction.

Best fit: Care delivery, payer-provider

Growth equity for scaling health-tech with proven traction. Series B+, $20M-$100M. Notable: DexCare. Targets post-pilot businesses with enterprise validation and growth-stage metrics.

Best fit: Healthcare scaling, payer-tech

Early-stage healthcare investor with concentrated, thematically coherent digital health portfolio. Focus on infrastructure, AI diagnostics, virtual specialty care, and women’s health. Operator-led.

Best fit: AI diagnostics, women's health

Nashville-based healthcare-only VC. Founded by Bill Frist (former Senate Majority Leader, surgeon) and Bryan Cressey. Investments span tech-enabled services, behavioral health, value-based care, and digital health.

Best fit: Value-based care, behavioral

London-based VC founded by Niklas Zennström (Skype). Series A and onwards investments in European technology companies across digital health, AI, and consumer. Major European multi-stage scaling partner.

Best fit: European scaling

Trans-Atlantic VC investing in startups with global business potential. Founded 1996. Strong digital health and health AI portfolio with offices in London, San Francisco, and New York. Top-5 European digital health investor per Galen Growth.

Best fit: Healthcare AI, trans-Atlantic

Paris-based investment firm with significant venture and growth healthcare presence. #2-ranked European digital health investor per Galen Growth HT50 2025. Multi-stage capital across digital health, life sciences, and software.

Best fit: European multi-stage

Healthcare-specialist VC focused on serving Medicare, Medicaid, and other underserved populations through value-based care and care delivery innovation. Founded by Andy Slavitt (former CMS Administrator), Trevor Price, and David Whitrap. Series A through growth. Notable: Cityblock Health, Strive Health.

Best fit: VBC, Medicare/Medicaid, care delivery

Global growth equity firm with major digital health and healthcare practice. A top-5 European digital health investor by deal activity. Notable: Doctolib, Ro, Modern Animal. Multi-stage but anchored at growth.

Best fit: Pre-IPO scale, consumer health

Crossover hedge fund and VC. Major late-stage investor in digital health unicorns during the 2020-22 boom (Cerebral, Ro, Capsule, Forward). Has become substantially more selective since 2022, with fewer but more concentrated late-stage digital health bets.

Best fit: Late-stage selective

New York-based public-private crossover with technology and healthcare focus. Late-stage venture and growth equity. Notable digital health: Hims, Carbon Health, Ada Health, Komodo Health.

Best fit: Pre-IPO crossover, healthcare AI

Public-markets investor with active venture-stage crossover practice in healthcare. Top-5 clinical-evidence investor per Galen Growth HT50 2025. Provides bridge to public markets for pre-IPO companies.

Best fit: Pre-IPO crossover

Major public-markets crossover investor with significant late-stage digital health activity (via Fidelity Management & Research Company, ranked top-5 late-stage per Galen Growth HT50 2025). Sister fund F-Prime Capital invests at venture stages.

Best fit: Pre-IPO crossover

World’s largest asset manager with active late-stage and crossover practice. Healthcare innovation team backs growth-stage digital health, biotech, and medtech. Provides scale capital and public-market continuity.

Best fit: Pre-IPO crossover

#1 ranked late-stage digital health investor per Galen Growth HT50 2025 -- and #1 for clinical-evidence-led ventures. Bridges private-late-stage and public markets for digital health and TechBio companies.

Best fit: Clinical evidence, TechBio

$100B+ mega-fund with healthcare and AI healthcare investing. #2 ranked late-stage digital health investor per Galen Growth HT50 2025. Activity has substantially moderated from 2020-22 peak; current strategy emphasizes selective, concentrated late-stage bets. Notable: Cerebral, Pacific Biosciences, Roivant.

Best fit: Late-stage selective

Global healthcare crossover with significant late-stage digital health and biotech activity. #3 ranked late-stage digital health investor per Galen Growth HT50 2025. U.S., European, and Asian growth-stage investments.

Best fit: Global crossover

Healthcare-dedicated investment firm (founded 1999 by Joseph Edelman, ~$8.5B AUM) spanning public equities, credit, and venture through its Perceptive Xontogeny Venture Fund. Ranked #4 late-stage and #3 clinical-evidence investor per Galen Growth HT50 2025 -- a notable gap in prior editions of this directory.

Best fit: Late-stage crossover, clinical evidence

San Francisco crossover specialist. Venture, growth, and crossover healthcare investing since 2007. Notable: BioNTech, Virta Health. Strong fit for healthcare companies on a public-markets trajectory.

Best fit: Crossover venture-to-IPO

NYC healthcare investor since 1994. Capital, information, and philanthropy across the healthcare spectrum. Seed through post-IPO. Notable: Nuvalent, Viatris. Highly active across digital health, devices, and therapeutics.

Best fit: Multi-stage healthcare

Bain Capital’s dedicated life sciences and healthcare arm. Growth equity and late-stage investing across biotech, medtech, healthcare services, and digital health. Strong partnership with operating companies.

Best fit: Healthcare PE, growth

Evidence-based, multi-stage healthcare and life-sciences investor (founded 2001/2004, ~$12.6B AUM) spanning seed through public markets. Runs Raven, an internal healthcare incubator, and TechAtlas, a proprietary research engine. Ranked #3 TechBio investor per Galen Growth HT50 2025, behind only Insight Partners and GV.

Best fit: TechBio, evidence-based healthcare

Global multi-stage VC with dedicated healthcare practice spanning healthtech, digital health, medtech, biotech, and AI-enabled infrastructure. $7B+ AUM. Notable: Hippocratic AI, Atomwise. Strong cross-border capability connecting U.S. and Asia healthcare markets.

Best fit: Healthcare AI, infrastructure, global

Healthcare-only growth equity firm investing in commercial-stage technology, services, and medtech companies. $20M-$80M check size. Notable digital health: Capital Rx. Patient capital with operating support for scaling teams.

Best fit: Healthcare scaling, commercial-stage

#1 ranked growth-stage digital health investor per Galen Growth HT50 2025. CVS Health’s strategic VC arm reflecting an increasingly muscular role in care delivery, pharmacy, and benefits through digital tools.

Best fit: Pharmacy benefits, distribution

UnitedHealth Group’s strategic venture arm. Seed to growth equity across value-based care, enterprise software, and enabling infrastructure. 70+ portfolio companies. Strategic LP relationship with Optum’s payer/provider/pharmacy ecosystem.

Best fit: Value-based care, infrastructure

Strategic VC of Kaiser Permanente, the integrated care system. Backs digital health platforms aligned with Kaiser’s care model and values, with potential for system-wide deployment validation.

Best fit: Integrated care system deployment

Cigna’s strategic venture investing arm. $250M committed capital. Focus on care delivery innovation, health analytics, and member engagement platforms aligned with Cigna’s integrated health services strategy.

Best fit: Member engagement, health analytics

Merck’s $500M+ digital health and tech-enabled health services fund. Multi-stage investments in companies that could create new business models for healthcare. Strong portfolio in clinical trials infrastructure, RPM, and patient engagement.

Best fit: Clinical trials infrastructure, RPM

Multi-Blue strategic VC with capital commitments from multiple BCBS affiliates. Invests in payer-aligned digital health platforms across care management, member experience, and risk adjustment.

Best fit: Multi-payer, member experience

Strategic VC of Ascension. 13 health system LPs giving portfolio companies network of 100+ U.S. hospitals for go-to-market validation. Notable: Iodine, Verata, AristaMD.

Best fit: Multi-system deployment

EU-funded innovation network and investment vehicle. Backs European health-tech and digital health startups with both grant capital and venture investment. Cross-border deployment support and pan-European clinical validation pathways.

Best fit: European health innovation

KKR’s dedicated healthcare growth equity strategy. Invests in scaled digital health, healthcare services, and tech-enabled providers. Provides PE-scale capital and operational playbooks for late-stage and pre-IPO companies.

Best fit: Healthcare PE, late-stage scale

Strategic healthcare venture firm jointly backed by Cambia Health Solutions and Mosaic Health (BCBS). Multi-stage investment from Series A through growth across payer/provider transformation, healthcare distribution, and scaling digital health platforms.

Best fit: Payer-aligned, distribution

Strategic VC of MemorialCare health system. Backs digital health, AI, and care delivery innovation aligned with health-system priorities. Provides clinical workflow piloting environment and deployment validation for portfolio companies seeking U.S. health system traction.

Best fit: Health system deployment, clinical workflow

Healthcare VC firm spun out from Providence Health (renamed January 2025; previously Providence Ventures). $150M third fund anchored by Providence, with plans to add other health-system LPs. Mid- to late-stage venture investments in healthcare IT, MedTech, and tech-enabled services. Notable portfolio: Omada, DexCare, Kyruus, Xealth, Trilliant Health.

Best fit: Health system deployment, mid-late stage

Mass General Brigham’s AI and Digital Innovation Fund. Companion to MGB Ventures (which focuses on internal research). AIDIF concentrates on commercial-stage digital health and AI-based externally developed solutions, with co-development and clinical workflow integration through MGB’s health system. Notable: DexCare, CARTA Healthcare.

Best fit: Healthcare AI, clinical AI deployment